The significance of evaluating conventional inflammatory markers in Von Willebrand factor measurement.
Lippi G , Franchini M , Targher G , Poli G , Guidi GC |.
METHODS: To investigate the relationship between conventional inflammatory markers and VWF, 387 consecutive unselected patients undergoing surgical procedures at our University Hospital were systematically investigated for routine laboratory testing, including also VWF Antigen (VWF:Ag), C-reactive protein (CRP) and the erythrocyte sedimentation rate (ESR) as parts of a routine preoperative screening program.
A significantly different frequency distribution of VWF:Ag concentrations was also observed in subjects with values of inflammatory markers above the upper limits of the reference ranges when compared to those with normal values.
In particular, the prevalence of subjects with VWF:Ag levels>120 UI/dL was six- and nearly three-times higher in subjects with abnormal values of CRP (55.8% versus 9.3%, p<0.001) and ESR (54.5% versus 18.7%, p<0.001), respectively.
CONCLUSIONS: Results of this investigation demonstrate that the evaluation of conventional inflammatory markers would represent a valuable tool to enhance the clinical usefulness of VWF measurements, especially in patients with transitory and subclinical inflammation.
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